PAMAM dendrimer - cell membrane interactions
نویسندگان
چکیده
منابع مشابه
Molecular analysis of interactions between a PAMAM dendrimer-paclitaxel conjugate and a biomembrane.
Understanding the underlying mechanism of nanomedicine-biomembrane interactions is important for the design and optimization of payload delivery systems. This study investigates the interactions between polyamidoamine (PAMAM) dendrimer-paclitaxel conjugates and biomembranes using coarse-grained molecular dynamics simulations. We found that acidic conditions (e.g., pH ∼ 5) and membrane asymmetry...
متن کاملSynthesis and Characterization of Doxorubicin-bearing Cetuximab-PAMAM Dendrimer Bioconjugates
876 ©2014 Society for Biomaterials
متن کاملDiffusion NMR Study of Generation-Five PAMAM Dendrimer Materials
Commercial generation-five poly(amidoamine) dendrimer material (G5c) was fractionated into its major structural components. Monomeric G5 (G5m; 21--30 kDa) was isolated to compare its functional properties to the G5c material. Diffusion-ordered nuclear magnetic resonance spectroscopy was employed to measure the self-diffusion coefficients and corresponding hydrodynamic radii of G5m and other G5c...
متن کاملIn Vitro Evaluation of Third Generation PAMAM Dendrimer Conjugates.
The present study compares the use of high generation G3 and low generation G0 Polyamidoamine (PAMAM) dendrimers as drug carriers of naproxen (NAP), a poorly water soluble drug. Naproxen was conjugated to G3 in different ratios and to G0 in a 1:1 ratio via a diethylene glycol linker. A lauroyl chain (L), a lipophilic permeability enhancer, was attached to G3 and G0 prodrugs. The G3 and G0 conju...
متن کاملLow-temperature activation conditions for PAMAM dendrimer templated Pt nanoparticles.
Surface immobilized polyamidoamine (PAMAM) dendrimer templated Pt nanoparticles were employed as precursors to heterogeneous catalysts. CO oxidation catalysis and in situ infrared spectroscopy were used to evaluate conditions for dendrimer removal. Infrared spectroscopy showed that PAMAM dendrimer amide bonds begin decomposing at temperatures as low as 75 degrees C. Although the amide stretches...
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ژورنال
عنوان ژورنال: Advances in Colloid and Interface Science
سال: 2018
ISSN: 0001-8686
DOI: 10.1016/j.cis.2018.06.005